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  • Metastatic castration-resistant prostate cancer (mCRPC)
    Metastatic prostate cancer happens when the cancer spreads from the prostate to other parts of the body Sometimes the cancer spreads and hormone therapy helps control it This is called metastatic castration-sensitive prostate cancer (mCSPC) If the cancer spreads and no longer responds to hormone therapy medicines, it's considered mCRPC
  • Advanced and metastatic prostate cancer: ESMO Clinical Practice . . .
    This ESMO Clinical Practice Guideline (CPG) focuses on advanced and metastatic prostate cancer This includes metastatic castration-sensitive prostate cancer (mCSPC), non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic castration-resistant prostate cancer (mCRPC)
  • TALZENNA Plus XTANDI Significantly Improves Radiographic Progression . . .
    Prostate cancer is the second most common cancer in men worldwide, with an estimated 1 4 million new cases diagnosed globally in 2022 1 and 330,000 new cases anticipated in the United States in 2026 2 mCSPC, is a form of advanced prostate cancer that has spread beyond the prostate but is still sensitive to androgen inhibition 3 Despite recent
  • Niraparib and abiraterone acetate plus prednisone for HRR-deficient . . .
    We hypothesized that PARP inhibition within 6 months of starting androgen deprivation therapy for metastatic castration-sensitive prostate cancer (mCSPC) could be effective and improve
  • Phase III Study: Saruparib Combo w. . . | Advanced Prostate. . .
    The safety and efficacy of saruparib plus new hormonal agents for the treatment of mCSPC and mCRPC are being assessed in the Phase I IIa PETRANHA study (NCT05367440), with the initial data indicated that saruparib (60 mg QD) can be safely combined with enzalutamide, abiraterone acetate, or darolutamide
  • Advanced Prostate Cancer: AUA SUO Guideline (2026)
    The management of advanced prostate cancer is rapidly evolving To assist in clinical decision-making, evidence-based guideline statements were developed to provide a rational basis for evidence-based treatment This guideline covers advanced prostate cancer, including disease stages that range from prostate-specific antigen (PSA) recurrence after exhaustion of local treatment options to
  • CUA Call-to-Action: Advanced Prostate Cancer (mCSPC) – 2026 Update . . .
    Apply the latest guideline recommendations and evidence to optimize disease characterization and treatment selection in mCSPC Integrate advanced imaging, biomarker, and genetic testing into clinical decision-making to personalize therapy
  • The Current State of Treatment Implementation for mCRPC in . . . - UroToday
    There have been significant advances in the metastatic castrate-resistant prostate cancer (mCRPC) treatment landscape with the emergence and approval of numerous agents in this disease space Despite these regulatory approvals, supplemented by international guidelines recommendations in favor of
  • Erleada Shows Survival Advantage in Real-World Study of Metastatic . . .
    A real-world study found Erleada reduced the risk of death compared with Nubeqa in patients with metastatic castration-sensitive prostate cancer
  • Real-world head-to-head analysis shows 51% reduction in risk of death . . .
    HORSHAM, PA, February 2, 2026 – Johnson Johnson today announced new real world head-to-head evidence demonstrating that patients with metastatic castration-sensitive prostate cancer (mCSPC) initiating ERLEADA ® without docetaxel experienced a statistically significant 51 percent reduction in the risk of death compared to those who initiated on darolutamide without docetaxel through 24





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