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  • Imetelstat Sodium - NCI - National Cancer Institute
    Imetelstat sodium works by blocking the activity of an enzyme called telomerase, which is found at high levels in cells that divide rapidly, including cancer cells Blocking this enzyme keeps cancer cells from dividing and causes them to die Imetelstat sodium is a type of targeted therapy called an enzyme inhibitor
  • Imetelstat (Rytelo®) - OncoLink
    Imetelstat (Rytel®) is a telomerase inhibitor used in the treatment of myelodysplastic syndrome (MDS)
  • Imetelstat-mediated alterations in fatty acid metabolism to induce . . .
    Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in myelofibrosis and myelodysplastic syndromes
  • Imetelstat (RYTELO) National Drug Mini-Monograph July 2025
    The results suggested that, in RBC-TD patients with LR-MDS anemia who relapsed after initial response to ESA, were refractory to ESA, or were ineligible for ESA, imetelstat produced durable (up to 1 year) RBC-TI, reduced transfusion burden, and improved Hg Unlike other treatments, imetelstat efficacy remained robust regardless of ring sideroblasts (RS) and high transfusion burden Achievement
  • Imetelstat in patients with lower-risk myelodysplastic syndromes who . . .
    Consistent with previous studies, grade 3 or 4 neutropenia and thrombocytopenia were reported more frequently in patients treated with imetelstat compared with those who received placebo, but these treatment-emergent adverse events were reversible and manageable
  • Imetelstat, a novel, first-in-class telomerase inhibitor: Mechanism of . . .
    Most cancers and neoplastic progenitor cells have elevated telomerase activity and preservation of telomeres that promote cellular immortality, making telomerase a rational target for the treatment of cancer Imetelstat is a first-in-class, 13-mer oligonucleotide that binds with high affinity to the template region of the RNA component of human telomerase and acts as a competitive inhibitor of
  • Oncology Drug Reference Sheet: Imetelstat | Oncology Nursing Society
    In June 2024, imetelstat (Rytelo™) became the first telomerase inhibitor approved by the U S Food and Drug Administration (FDA) Imetelstat treats low- to intermediate-risk myelodysplastic syndromes in adults with transfusion-dependent anemia
  • Imetelstat: A First-in-Class Telomerase Inhibitor for the Treatment of . . .
    Abstract Imetelstat is a first-in-class, direct, and competitive inhibitor of telom-erase enzymatic activity that selectively induces apoptosis of ma-lignant clones and allows for recovery of erythropoiesis Imetelstat was approved by the United States Food and Drug Administration in June 2024 and the European Medicines Agency in March 2025 for the treatment of certain patients with lower-risk
  • First Real-World Evidence Study of RYTELO® (imetelstat) in Lower-risk . . .
    “Imetelstat has become an important treatment option for patients with lower-risk myelodysplastic syndromes experiencing anemia and red blood cell transfusion burden, particularly in patients previously treated with ESAs or other therapies,” said David A Sallman, M D , Associate Member, Malignant Hematology Department, Moffitt Cancer Center “As treatment sequencing has emerged as an
  • Imetelstat Sustains Significant Survival Benefit in R R Myelofibrosis
    An updated post hoc analysis from the phase 2 IMbark trial (NCT02426086) has reaffirmed that the telomerase inhibitor imetelstat delivers a clinically meaningful and statistically significant overall survival (OS) benefit compared with best available therapy (BAT) in patients with JAK inhibitor (JAKi)–relapsed or refractory (R R) intermediate





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